Context-dependent signalling

Signalling pathways modulate cellular responses in developmental and regenerative processes but can also be misused by cancer cells to promote tissue invasion and growth. How signalling outputs are integrated to direct a variety of responses ranging from organ repair to tumour onset remains elusive. Jorge Beira and collaborators at ETH Zürich (Switzerland) revealed that similar signals and pathways are differentially regulated during tissue regeneration on the one hand, and tumorigenesis on the other. Interestingly, signalling hierarchies active in Drosophila ph tumours are distinct from the role these same pathways have in protecting normal tissues undergoing stress or injury, thus promoting regeneration.

The paper entitled "Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing" was published in PLoS Genetics.